E-ISSN 2149-2530
Original Article
Pulmonary function changes in COPD patients according to smoking status Short title: PF changes in COPD according to smoking
1 Interdisciplinary Allergy Outpatient Clinic, Department of Pneumology, University of Lübeck, Germany  
Turk Thorac J ; 5: -
DOI: 10.5152/TurkThoracJ.2019.18135
Key Words: Smoker, quitter, non-quitter, COPD, pulmonary function
Abstract

OBJECTIVE: The aim of our study was to examine respiratory functions according to smoking cessation status in patients across all stages of COPD who are currently smoking.

 

MATERIAL AND METHODS: This retrospective case–control study was carried out. A total of 148 patients were enrolled, and divided into two groups (quitters, n=68, and non-quitters, n=80). Pulmonary function parameters, COPD assessment test score, Fagerström Nicotine Addiction Questionnaire score, smoking history and status were obtained from the electronic hospital data system. Patients' admission and 12-month data were recorded.

 

RESULTS: In non-quitters, the mean FEV1 values decreased from 2.32 ± 1.14 to 2.24 ± 1.12 (P < 0.001). Particularly in Stage-0, at early high risk group of COPD, the reduction in FEV1 was 90 mL, while the reduction was 70, 60, 40, and 40 mL in Stages-I, -II, -III, and -IV, respectively. In quitters, the mean FEV1 levels increased from 2.10 ± 1.19 to 2.19 ± 1.20 (P < 0.001). For COPD patients overall, an average increase of 80–110 mL in FEV1 was observed. At the end of 12 months‘ follow-up, 17 (27.5%) of the non-quitters showed deterioration, and five (7.3%) of the quitters showed improvement in COPD stage.

 

CONCLUSION: FEV1 decline is accellerated in COPD patients who continue to smoke, and this decline was not prevented by inhaler treatments. The GOLD Stage-0 group, which is not included in the current guidelines, needs to be redefined, and this group is the most important in terms of prevention of the disease.

 

Cite this article as: Gülşen A. Pulmonary function changes in COPD patients according to smoking status. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2019.18135

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