E-ISSN 2149-2530
Original Article
IS INDUCED SPUTUM A USEFUL NONINVASIVE TOOL IN DIAGNOSIS OF PULMONARY SARCOIDOSIS?
1 Kyrenia Akcicek National Hospital, Department of Pulmonary Medicine, Cyprus  
2 Dışkapı Yıldırım Beyazıt Research and Education Hospital, Departmen of Pulmonary and Critical Care Medicine, Intensive Care Unit, Ankara, Turkey  
3 Institute of Pulmonary Diseases, National Laboratory Service for ILD, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel  
4 Gazi University Faculty of Medicine, Department of Microbiology, Ankara, Turkey  
5 Gazi University Faculty of Medicine, Department of Pulmonary Medicine, Ankara, Turkey  
Turk Thorac J ; 5: -
DOI: 10.5152/TurkThoracJ.2018.180147
Key Words: Clinical problems, diagnostic methods, ınterstitial lung disease
Abstract

OBJECTIVE: Provokation of sputum expectoration by inhalation of hypertonic saline (NaCl) has been investigated as an alternative diagnostic tool to invasive procedures in patients with pulmonary sarcoidosis. We aimed to investigate the diagnostic value of IS by looking at cell distribution of sputum in patients with confirmed histopathological diagnosis of sarcoidosis.


MATERIAL AND METHODS
: In this prospective, cross sectional study, we compared IS results of twenty histopathologically confirmed pulmonary sarcoidosis patients with twenty-four healthy volunteers. Percentages of macrophages, lymphocytes, neutrophils, eosinophils in IS, and the CD4+/CD8+ ratio were compared.


RESULTS
: The percentage of lymphocytes in IS was significantly higher in pulmonary sarcoidosis than the control group (41.6% vs 8.9%, p<0.001). There were no significant differences in the other IS cell percentages and CD4/CD8 ratio between the groups. Sputum induction was well tolerated.


CONCLUSION
: Induced sputum (IS) by inhalation of hypertonic saline is safe, inexpensive, less invasive, and easily repeated method can be a valuable diagnostic tool alternative to other invasive diagnostic methods in the diagnosis of pulmonary sarcoidosis.


Cite this article as
: Baha A, Yıldırım F, Stark M, et al. IS INDUCED SPUTUM A USEFUL NONINVASIVE TOOL IN DIAGNOSIS OF PULMONARY SARCOIDOSIS? Turk Thorac J 2018; DOI: 10.5152/TurkThoracJ.2018.180147

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