E-ISSN 2149-2530
Original Article
Serum Albumin is a Biomarker of Chronicity of Pulmonary Sarcoidosis
1 Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Miami, FL, USA  
2 Internal Medicine Department, Mercy Medical Center, Clinton, Iowa, USA  
3 Division of Rheumatology, University of Illinois at Chicago, Chicago, IL, USA  
Turk Thorac J ; 5: -
DOI: 10.5152/TurkThoracJ.2018.094
Key Words: Pulmonary sarcoidosis, hypoalbuminemia, serum albumin
Abstract

OBJECTIVE:  The duration of sarcoidosis is associated with a higher risk of irreversible pulmonary fibrosis. Sarcoidosis manifests diverse clinical presentations, which, may lead to delayed diagnosis, due to lack of specific diagnostic test. Biomarkers of sarcoidosis duration have not been previously explored.


MATERIAL AND METHODS
: A retrospective study was conducted to investigate independent biomarkers of pulmonary sarcoidosis duration.


RESULTS
: 108 cases with pulmonary sarcoidosis (mean age 53.4 years, 76.9% females, average duration of sarcoidosis 12 years) were included in the study. We found significant correlation between duration of sarcoidosis and serum albumin levels (r= -0.414, P=0.0001), sedimentation rate (ESR) (r= 0.375, P=0.001), pulmonary artery systolic pressure (PASP) (r= 0.468, P=0.003), diffusion capacity (DLCO%) (r= -0.334, P=0.002) and age (r= 0.492, P=0.0001). Multivariate linear regression analysis revealed that serum albumin levels (β= -5.242, 95% CI -8.372 to -2.112, P=0.001) and age (β= 0.367, 95% CI 0.164 to 0.570, P=0.001) were independent correlates of sarcoidosis duration. ROC curve analysis for prediction of sarcoidosis of >10 years duration gave AUC of 0.722 (95% CI 0.620-0.824, P<0.0001) for serum albumin and an AUC of 0.665 (95% CI 0.561-0.768, P<0.004) for age.  An albumin level <2.4 gm/dL yielded 90.5% sensitivity and 98.2% specificity for predicting sarcoidosis of >10 years duration.  In comparison, patient age of 51.5 years yielded 70.2% sensitivity and 50% specificity for predicting patients with sarcoidosis for >10 years.



CONCLUSION
: Serum albumin level may be a biomarker of pulmonary sarcoidosis duration and chronicity of disease.  Further investigations are required to confirm its predictive ability.


Cite this article as
: Isma SJ, Omar HR, Sweiss N, et al. Serum Albumin is a Biomarker of Chronicity of Pulmonary Sarcoidosis. Turk Thorac J 2018; DOI: 10.5152/TurkThoracJ.2018.094

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