E-ISSN 2149-2530
Original Article
Characteristics of Patients with Large-Cell Neuroendocrine Carcinoma of the Lung
1 Health Sciences University Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital İzmir, İzmir, Turkey  
Turk Thorac J ; 5: -
DOI: 10.5152/TurkThoracJ.2019.180166
Key Words: large-cell neuroendocrine carcinoma of the lung, progression-free survival, overall survival, stage, TTF-1
Abstract

Aim: Lung’s Neuroendocrine tumors are a clearly different group of tumors that have definite ultrastructural, immunohistochemical, and molecular features. We reported and analyzed the incidence, clinicopathologic features, rates of surgery, responses to first-line therapy, and survival outcomes of this rare tumor of the lung according to our lung cancer patient database.

 

Methods:  62 patients with Large Cell Neuroendocrine Carcinoma of Lung (LCNEC) who were diagnosed histopathologically between January 2010 and January 2016 recorded retrospectively.

 

Results: The patients' average age was 60.3±8.6. Male predominated %95 (male/female= 59/3). Diagnosis was made by the fine-needle aspiration biopsy (NAB) in 7 patients, bronchoscopic transbronchial biopsy (TBB) in 13 patients and surgery in 42 patients. Most commonly tumor was localized in the right upper lobe (43.5%). Also, 46.8% of all patients were in peripheral location. Sixteen patients were stage 1, 17 patients were stage 2, 15 patients were stage 3 and 14 patients were stage 4. Median progression-free survival (PFS) was 29 months (SE:12.2) (95% CI, 5.2–52.8 months). Progression-free survival (PFS) was significantly better in patients who have low N, M0, early stage, p63 positive and TTF-1 positive across the whole cohort. Overall survival (OS) was significantly better in patients who have low N, M0, low stage, peripheral location across the whole cohort.

 

Conclusion: Our study demonstrates a single center experience with clinicopathologic factors and survival outcomes of LCNEC patients, which is a rare group of thoracic malignancies.

 

 

Cite this article as: Çırak AK, Ceylan KC, Varol Y, et al. Characteristics of Patients with Large-Cell Neuroendocrine Carcinoma of the Lung. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2019.180166

 

 

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