E-ISSN 2149-2530
Original Article
Evaluation of Treatment Indications, Tuberculin Skin Test, and Bacillus Calmette-Guerin Vaccination Scars in the Cases of Latent Tuberculosis Infection Treatment
1 Ankara Tuberculosis Control Dispensary, Ankara, Turkey  
Turk Thorac J 2018; 19: 7-12
DOI: 10.5152/TurkThoracJ.2017.17027
Key Words: Tuberculin skin test, bacillus Calmette-Guerin vaccine, isoniazid, latent tuberculosis infection treatment

OBJECTIVES: The aim of our study was to evaluate the latent tuberculosis infection (LTBI) treatment application and to investigate if there is change between tuberculin skin test (TST) results according to bacillus Calmette-Guerin (BCG) scar numbers after LTBI treatment with isoniazid (INH).


MATERIAL AND METHODS: Data were collected from the LTBI treatment files from the dispensary of 2006. The results were statistically evaluated.


RESULTS: Latent tuberculosis infection was administered to 253 cases in 2006. The male/female case rate was 51/49. The age of most patients was under 15 years out of 14 cases. The mean age was 8.92±6.87 years (range, 0-84 years). One case had liver function test abnormality and INH was stopped in the first month of treatment. The completion rate of LTBI treatment was 95%. BCG vaccination rate was 93%. Active tuberculosis did not develop during the LTBI treatment in our study. Of all the cases, 221 scar numbers and TST were full. Of all cases 221 the scar numbers and TST value were full.TST of the 221 cases according to BCG vaccine scar numbers and indications were compared pre- and post-treatment with INH. Indications for LTBI treatment in these cases were close contact with smear-positive active pulmonary tuberculosis cases (n=77, 35%), TST-positive children aged <15 years (n=138, 62%), and the other (n=6, 3%) immunosuppressed patient cases. After treatment with INH, TST values decreased in the TST-positive children aged <15 years with one and 2 scars, with a statistically significant this result were found statistically significant (p<0.05).


CONCLUSION: The age of patients in most cases with LTBI treatment was under 15 years. The treatment completion rate and BCG vaccination rate were high. One case had liver function test abnormality. Active tuberculosis did not develop during the LTBI treatment. In the group with TST-positive children aged <15 years with one and 2 BCG vaccine scars, the decrease between pre- and post-treatment TST results showed a statistically significant difference.



Cite this article as: Çakar B. Evaluation of treatment indications, tuberculin skin test, and bacillus Calmette-Guerin vaccination scars in the cases of latent tuberculosis infection treatment. Turk Thorac J 2018; 19: 7-12.

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