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In this article, we report a 62-year-old man with pulmonary, prostate, epididimys and testes tuberculosis. This patient was referred to our hospital with a history of cough and sputum of over 5 months duration, weight loss, scrotal edema and frequent urination. Sputum acid fast bacilli smear test of the patient was positive. Thorax computerized tomography showed multiple small cavitary lesions. Reticulonodulary infiltrations and granulomas with caseification necrosis were demonstrated on prostate biopsy. The patient, diagnosed as a case of pulmonary tuberculosis with genitourinary involvement, received antituberculosis treatment for 9 months and all symptoms regressed with this treatment. An epididimectomy was also performed to exclude malignancy.