Turkish Thoracic Journal
Original Article

Chlamydia pneumoniae and Helicobacter pylori Seropositivity in Sarcoidosis

1.

Ege Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, İzmir

2.

Ege Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İzmir

3.

Dokuz Eylül Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, İzmir

Turk Thorac J 2000; 1: 50-53
Read: 512 Downloads: 96 Published: 18 July 2019

Abstract

 

Sarcoidosis is a granulomatous disorder with unknown etiology and different hypotheses are used to explain the cause of the disease. We designed a prospective study in order to investigate the seroprevalance of Chlamydia pneumoniae and Helicobacter pylori infections in sarcoidosis. Thirty-three patients (8 males, 25 females, mean age 43.2±11.2) diagnosed as sarcoidosis by means of histopathological and clinical presentations and 17 healthy control subjects (6 males, 11 females, mean age 43.7±5.8) were enrolled in the study. Anti-Chlamydia pneumoniae IgG and anti-Helicobacter pylori IgG antibodies were investigated by microimmunofluorescence (MIF) and enzyme immunoassay (EIA), respectively. The fluorescence at 1/16 dilution for Chlamydia pneumoniae IgG antibodies and 20U/ml for Helicobacter pylori were accepted as positive. The Chi-square test was used for statistical analysis between groups. The anti-Chlamydia pneumoniae IgG was found positive in 26 patients (79%) with sarcoidosis and 12 control subjects (71%). The anti-Helicobacter pylori IgG was positive in 17 patients (52%) with sarcoidosis and 9 (53%) of the healthy controls. The differences were not statistically significant between sarcoidosis patients and controls for the positivity of Chlamydia pneumoniae IgG antibodies and Helicobacter pylori (c2=0.41and c2=0.0009, P>0.05 respectively). The study indicates that there is no sufficient evidence for a role of Chlamydia pneumoniae and Helicobacter pylori infections in the etiology of sarcoidosis.
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EISSN 2149-2530