Turkish Thoracic Journal
Original Article

Correlation between the Diagnostic Yield from the Bronchoalveolar Lavage Fluid Analysis and Clinicoradiological Findings in Sarcoidosis

1.

Çanakkale State Hospital, Department of Pulmonology, Çanakkale, Turkey

2.

Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pulmonology, İstanbul, Turkey

3.

Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Radiology, İstanbul, Turkey

Turk Thorac J 2020; 21: 21-26
DOI: 10.5152/TurkThoracJ.2018.180140
Read: 34 Downloads: 20 Published: 02 August 2019

Objective: The diagnosis of sarcoidosis is challenging at most times, requiring a search for less-invasive, more reliable diagnostic methods. Bronchoalveolar lavage fluid (BALF) analysis has been used in the differential diagnosis of sarcoidosis for many years with a wide sensitivity and specificity rates. The objective of the study is to investigate whether diagnostic performance of BALF analysis is altered by clinicoradiological findings of sarcoidosis patients.

Material and Methods: The present study is a retrospective, single center, observational study designed in a sarcoidosis outpatient clinic in a training hospital. Patients who had undergone BAL procedure at diagnosis were included in the study. Demographics, clinical and detailed chest X-ray and high resolution computed tomography (HRCT) findings at diagnosis were recorded. According to diagnostic performance, BALF results were Grouped as `diagnostic` and `non-diagnostic` and recorded parameters were compared between the Groups.

Results: Of all the 257 patients’ BALF analysis, the mean lymphocyte ratio was 41±17.5 (5-80) and the mean CD4/CD8 was 5.5±4.7 (0.1-24.7). BALF analysis was diagnostic in 56 % (n=145). Diagnostic performance of the procedure did not correlate with any of the demographics, smoking status,spirometric findings, chest X-ray staging, HRCT findings and tomography scoring. Extra-pulmonary involvement was significantly more frequent in diagnostic group (66% vs. 34%, P=0.006).

Conclusion: BALF results signal sarcoidosis in more than half of the patients. The diagnostic role of BALF is greater in patients with extra-pulmonary involvement.

Cite this article as: Tokgöz Akyıl F, Ağca M, Öztürk H, et al. Correlation between the Diagnostic Yield from the Bronchoalveolar Lavage Fluid Analysis and Clinicoradiological Findings in Sarcoidosis. Turk Thorac J 2020; 21(1):21-6.

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