Turkish Thoracic Journal
Original Article

DILATATION RESERVE OF PULMONARY ARTERIES AT STAGES OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE MODEL

1.

Research Institute of Pulmonology, I. P. Pavlov’s First Saint-Petersburg State Medical University, Russia

2.

Saint Petersburg State University, Russia

Turk Thorac J 0; 5: 0-0
DOI: 10.5152/TurkThoracJ.2019.18197
Read: 172 Downloads: 15 Published: 18 July 2019

Abstract

OBJECTIVE: to assess the state of pulmonary vascular mediator systems during the stepwise formation of COPD model.

 

MATERIAL AND METHODS: Model of COPD was induced in rats by nitrogen dioxide inhalation for 60 days. At the stages of COPD (15, 30 and 60 days) the effect of reagents-vasodilators (-adrenoreceptor agonist izoproterenol, nitric oxide donor nitrosorbid, acetylcholine, activator of C-fibers capsaicin, corticosteroid beclometasone) on the isolated pulmonary arteries (diameter < 0.5 mm) was studied. Vascular reactivity was assessed by determining isometric contraction (tension in mg) of arterial rings using electromechanical transducer.

 

RESULTS: All vasodilators dose-dependently decreased vascular tone of pulmonary arteries isolated from intact rats. After a 15-day of nitrogen dioxide exposure dilatation effect of low doses of vasodilators do not differ from the intact specimens. Functional state of the adrenergic system has deteriorated faster than non-adrenergic non-cholinergic system as reflected in the weakening of the izoproterenol relaxation effect. As prolongation nitrogen dioxide exposure pulmonary arteries responded to the impact of all vasodilators with smaller relaxation. Dose-dependence of the dilatation reaction disappeared for izoproterenol, capsaicin, beclometasone and was less expressed for nitrosorbid and acetylcholine after 60 day of exposure.

 

CONCLUSION: In the course of forming the COPD model generation the functioning of almost all neurotransmitter systems of pulmonary artery wall was broken. This led to a decrease in the influence of vasodilators on pulmonary artery vascular tone and could facilitate the development of pulmonary hypertension which is typical of COPD.

 

Cite this article as: Kuzubova NA, Lebedeva ES, Titova ON, et al. DILATATION RESERVE OF PULMONARY ARTERIES AT STAGES OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE MODEL. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2019.18197

EISSN 2149-2530
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