High Factor IX Level With a Factor V 1691 G-A Mutation in a Case of Pulmonary Thromboembolism

Thrombophilic risk factors are accused in the pathogenesis of venous thromboembolism. Recently high levels of factor IX ha­ve been shown to increase the risk of deep venous thrombosis. We experienced a case of pulmonary thromboembolism (PTE), who had no risk factors for venous thromboembolism and was evaluated for inherited thrombophilic risk factors. She had nor­mal Factor VIII level and no transition in the prothrombin ge­ne but she was found to have high level of factor IX (173 lU/dl) and Factor V 1691 G-A mutation. The patient was carrying two different thrombotic risk factors that were not reported before for the cause of PTE. The gene­tic basis of coagulopaty should be determined in all PTE pati­ents without a significant risk factor..