Thoracic Research and Practice

High-Flow Nasal Oxygen Therapy in Acute Hypoxemic Respiratory Failure: Concise Review on Technology and Initial Methodology


Pulmonology Department, Hospital Professor Doutor Fernando Fonseca, Lisbon, Portugal


Department of Anesthesiology and Reanimation, Dentistry Faculty, Çukurova University, Adana, Turkey


Clinical Pharmacy Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt


Pulmonology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal


Pulmonology Department, Hospital Pedro Hispano, Matosinhos, Portugal


Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia


Department of Anesthesiology, Director of Respiratory Therapy, American University of Beirut, Beirut, Lebanon


Department of Anaesthesia and Perioperative Medicine, Complejo Hospitalario Universitario de A Coruña, A Coruña, Galicia, Spain


Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran


Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T Popa”, Iasi, Romania


Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Raipur, India


Department of Anesthesia and Intensive Care, Sapienza University of Rome, Rome, Italy


Department of Anaesthesiology and Intensive Care Medicine University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany


Department of Sleep Disorders Center, Vita-Salute San Raffaele University, Milan, Italy


Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, USA


Division of Pulmonary and Critical Care Medicine University of Maryland School of Medicine Baltimore, USA


Primario Medicina Intensiva, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland


Respiratory Diseases Unit, General Hospital Sestri Levante, Sestri Levante, Italy


Department Morphology, Surgery And Experimental Medicine, Intensive Care Unit, University of Ferrara, Ferrara, Italy


Pulmonology Unit, Santa Maria Bianca Hospital, Mirandola, Italy


Respiratory Diseases Unit, Respiratory Intensive Care Unit, Policlinico Umberto I Sapienza University of Rome, Italy


Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain

Thorac Res Pract 2021; 22: 494-500
DOI: 10.5152/TurkThoracJ.2021.20213
Read: 683 Downloads: 210 Published: 01 November 2021

High-flow nasal cannula oxygen therapy (HFNCOT) system consists of an air/oxygen supply system capable of delivering up to 100% humidified and heated oxygen at a flow rate of up to 80 L/min. The system includes a blender, active humidifier, single heated tube, and nasal cannula. HFNCOT has many  physiological advantages compared with other standard oxygen therapies, such as anatomical dead space washout, more constant fraction of inspired oxygen, positive end-expiratory (PEEP) effect, supplement of adequate humidification and maintenance of muco-ciliary function. HFNCOT is mostly used for hypoxemic acute respiratory failure, although it also has other indications. HFNCOT is a common choice of physicians as its technology makes it more silent and comfortable. Though HFNCOT is used in many clinical settings, there is a lack of publications addressing devices and initial settings. We present a review on HFNCOT, with focus on device and application methodology.

Cite this article as: Guia M, Alpay N, Gerardo A, et al. High-flow nasal oxygen therapy in acute hypoxemic respiratory failure: Concise review on technology and initial methodology. Turk Thorac J. 2021; 22(6): 494-500.

EISSN 2979-9139