Turkish Thoracic Journal
Original Article

Histopathologic type of lung cancer and driver mutations in patients with chronic obstructive pulmonary disease(COPD) versus patients with Asthma and COPD Overlap : single-center retrospective study

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Respiratory Medicine, Kanazawa University Hospital, Ishikawa, Japan

Turk Thorac J 0; 5: 0-0
DOI: 10.5152/TurkThoracJ.2019.18100
Read: 350 Downloads: 39 Published: 18 July 2019

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer. The relationships between COPD and Asthma COPD Overlap (ACO) and histopathologic types of lung cancer and driver mutations remain unclear and need further study. The aim of this retrospective study was to examine the relationships between histopathologic type, frequency of the epidermal growth factor receptor (EGFR) driver mutations, and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements in lung cancers of patients with COPD and ACO. 

 

Materials and Methods: Pure COPD (n = 198) or ACO (n = 318) who were admitted to our ospital were reviewed.

 

Results: Lung cancers were identified in 43 (21.7%) patients with pure COPD and 54 (17.0%) patients with ACO. The following lung cancers were seen: patients with pure COPD had 19 (44.2%) adenocarcinomas, 13 (30.2%) squamous cell lung carcinomas (SCC), 8 (18.6%) small cell lung carcinomas (SCLC); patients with ACO had 23 (42.6%) adenocarcinomas, 23 (42.6%) SCC, 2 (3.70%) SCLC. Significantly more SCLC occurred in the patients with pure COPD (p < 0.05). Differences between the numbers of other histological types of lung cancer and numbers of driver mutations in the 2 groups of patients were not significant. 

 

Conclusion: The differences between patients with pure COPD and those with ACO in the rate of lung cancer and prevalence of EGFR mutations were not significant.

 

Cite this article as: Sakai T, Hara J, Yamamura K, et al. Histopathologic type of lung cancer and driver mutations in patients with chronic obstructive pulmonary disease(COPD) versus patients with Asthma and COPD Overlap : single-center retrospective study. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2019.18100

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