Thoracic Research and Practice
Original Article

Investigation of Susceptibility in Mycobacterium tuberculosis Isolates to Amoxycillin-Clavulanate by Using E-Test

1.

Celal Bayar Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klin. Mik. AD, Manisa

Thorac Res Pract 2000; 1: Toraks Dergisi 28-31
Read: 1470 Downloads: 585 Published: 18 July 2019

Abstract

 

In vitro susceptibility of 40 Mycobacterium tuberculosis isolates to amoxycillin-clavulanate, which were isolated from various clinical specimens and 33 of which were susceptible to first line-drugs and 7 of resistant to more than one antimycobacterial agents were investigated by using E-test. It was determinated that MIC50 and MIC90 values of amoxycillin-clavulanate for susceptible strains were 8 mg/ml and 96 mg/ml, respectively. These values in multiple-drug resistant M. tuberculosis isolates were found as 48 mg/ml and 256 mg/ml, respectively. According to the results of our study, amoxycillin-clavulanate combination has effective antimycobacterial activity especially against the susceptible strains.
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EISSN 2979-9139