Turkish Thoracic Journal
Original Article

The Relationship Between Lymphocytes and Anxiety and Depression in Pulmonary Tuberculosis

1.

Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, 7. Klinik, İstanbul, Türkiye

2.

Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Psikiyatri Ünitesi, İstanbul, Türkiye

3.

Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, 3. Klinik, İstanbul, Türkiye

Turk Thorac J 2010; 11: 112-116
DOI: 10.5152/ttd.2010.15
Read: 781 Downloads: 272 Published: 18 July 2019

Abstract

Objective: The aim of this study is to evaluate the relation between the level of depression and anxiety and peripheral blood T lymphocyte subpopulation in patients with active pulmonary tuberculosis.

 

Material and Method: Thirty-two consecutive patients newly diagnosed with active pulmonary tuberculosis were enrolled. Depression and anxiety were evaluated with Hamilton Scale and T lymphocytes with flow cytometry method.

 

 

Results: All the cases were male and the mean age was 30.66 (±11.58) years. The diagnosis was based on bacteriological analysis. Mean cell counts were (in mm3) leukocyte 9175 (±2252), lymphocyte 1764.56 (±790), CD3% 64.30 (±9.88) CD19% 7.79 (±3.45), CD4% 36.82 (±10.93), CD8% 26.64 (±10.00), CD16/56% 16.46 (±8.64), active T 6.19% (±3.14) and CD45% 93.75 (±4.11). Mean depression score was 1.91 (±2.66) and anxiety score was 1.47(±1.95). There was an inversely proportional, moderately significant statistical relationship between radiological dissemination of the disease and CD16/56 and active T cells. A moderately significant statistical decrease in CD16/56 level was observed with the higher depression score.

 

Conclusion: The relationship between depression and CD16/56 might indicate that the nervous system has probably a part in the signal pathway between APCs and NK T lymphocytes. Considering the importance of the NK cells in the battle with the bacilli, we can presume that the inverse relation of the depression scores with CD16/56 lymphocytes levels increases the predisposition to the disease. (Tur Toraks Der 2010; 11: 112-6)

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EISSN 2149-2530