Turkish Thoracic Journal
Original Article

The Role and the Right Dosage of Theophylline in Prevention of Ischemia-Reperfusion Injury of the Lung

1.

Marmara Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi AD, İstanbul

2.

İstanbul Tıp Fakültesi, Göğüs Cerrahisi AD, İstanbul

3.

İstanbul Tıp Fakültesi, Biyokimya AD, İstanbul

Turk Thorac J 2002; 3: 126-131
Read: 377 Downloads: 88 Published: 18 July 2019

Abstract

In this study, the role and the right dosage of theophylline, a methylxanthine derivative, in prevention of ischemia-reperfusion injury of the lung has been investigated.

This experimental study was done on 30 rats; in experimental group (EG) 1 (n:5) 20 mg/L, in EG 2 (n:5) 100 mg/L, in EG 3 (n:5) 400 mg/L and in EG 4 (n:5) 1000 mg/L theophylline added flush solution was perfused. Lungs were kept in hypothermic state for 6 hours and ventilated for 30 minutes with 100 % O2. Tissue levels of dien congugate (DC) and malondialdehyde (MDA) , intermediate products of lipid peroxidation, were measured. The results were compared to the 2 control groups.

Dien congugate and MDA levels in groups preserved with 400-1000 mg/L were significantly less than the other groups.

The results of this study showed that 400-1000 mg/lt of theophylline in the flush solution decreased the ischemic injury.

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EISSN 2149-2530