E-ISSN 2149-2530
Original Article
Newborn Screening for Cystic Fibrosis in Mersin Province: Yearly Assessment of the National Program
1 Pediatric Pulmonary Section, Department of Pediatrics, Mersin City Training & Research Hospital, Mersin  
2 Pediatric Allergy Section, Department of Pediatrics, University of Çukurova, Adana  
Turk Thorac J ; 5: -
DOI: 10.5152/TurkThoracJ.2019.18187
Key Words: cystic fibrosis, newborn screening, IRT test
Abstract

Objective: A national newborn screening program for cystic fibrosis (CF) has started by using immunoreactive trypsinogen (IRT) test on January 1, 2015 in Turkey. We aimed to analyze the characteristics of newborn screen positive (NBSP) infants in Mersin province.

 

Materials and Methods: The data of NBSP infants were retrospectively analyzed between years 2015 and 2017 from records of Hospital and Hospital.

 

Results: A total of 82,273 newborns were screened for CF by IRT test between years January 2015 and December 2017 in Mersin. Among those, 512 infants were defined as NBSP after two IRT tests (138 infants in 2015, 217 infants in 2016 and 157 infants in 2017, respectively). Sweat test was normal in the majority of infants [115 infants (83.3%) in 2015, 189 infants (87.1%) in 2016, and 129 infants (82.2%) in 2017]. Overall, after two repeated sweat tests, 4 infants had sweat test results in the intermediate range and 9 infants had positive sweat tests between years 2015 and 2017. The incidence of CF for a 3-year period was approximately 1/9300 in our region. The positive predictive value of IRT test for defining CF was 1.8% with a sensitivity of 90.0% and specificity of 99.4%.

 

Conclusion: IRT/IRT test as a newborn screening strategy provides the opportunity for earlier diagnosis and treatment of CF patients. More data are needed to understand the frequency of CF on a national base.

 

Cite this article as: Özdemir A, Doğruel D. Newborn Screening for Cystic Fibrosis in Mersin Province: Yearly Assessment of the National Program. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2019.18187

Key Words
Authors
All
Author's Corner
Survey
AVES | Copyright © 2019 Turkish Thoracic Society Latest Update: 20.06.2019